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The Simplified Acute Physiology Score (SAPS) II [13] was determined on admission

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Readouts should align with this compartment logic: deploy HyPer-ER or roGFP-Orp1 reporters to capture ER-confined H 2 O 2 dynamics (avoiding cytosolic averaging), track ER stress markers (e.g., BiP/GRP78, CHOP, spliced XBP1) to ensure adaptive, not terminal, UPR engagement and quantify downstream metabolic resilience (protein secretion fidelity, ATP/redox balance, sensitivity to secondary hits) to verify that interventions restore ER redox homeostasis and limit maladaptive crosstalk to mitochondria (Melo et al

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease