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4 Immunopharmacological implications Physiological levels of ROS, which are present in all living organisms, can activate both signaling pathways such as MAPK and ERK and transcription factors such as NF-B ( However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Figure 3)

Furthermore, nanoencapsulation techniques, such as incorporating polyphenols into nanoparticles (NPs) or liposomes, can further improve their bioavailability and biological activity (108)

In contrast, the choice of model architecture had relatively little impact

After 12 days, cell numbers varied between 9.2 10 6 cells mL 1 (1st sub-culture) to 2.2 10 7 cells mL 1 (8th sub-culture)