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Abbreviations AACE: American Association of Clinical Endocrinology AE: Adverse event CDS: Chinese Diabetes Society DPP-4i: Dipeptidyl peptidase-4 inhibitor ETD: Estimated treatment difference FPG: Fasting plasma glucose GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist PIONEER: Peptide Innovation for Early Diabetes Treatment SAE: Serious adverse event SF-36v2: 36-item Short Form Health Survey (Acute Version) SMPG: Self-monitored plasma glucose References Sun H, Saeedi P, Karuranga S et al (2022) IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

The highest level of acetylcarnitine incorporation into brain lipids is observed 1 h after injection and then gradually decreases, suggesting that the metabolic capacity to utilize the acute increase in acetyl groups may be limited and that the excess of acetyl groups is then rapidly incorporated into lipids

However, no attempt was made to ascertain if the available number of patients on GLP-1 agonist use or the number of events were enough for definitive conclusions

Neville JA, Welch E, Leffel DJ