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Microorganisms originating in the oral cavity can enter systemic circulation due to mechanical perturbations from daily activities such as brushing or chewing, ultimately reaching distant body sites and influencing their local microbiomes 37

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11 Semaglutide is FDA-approved for weight management in people with a body mass index of 30 or higher or 27 or higher with at least one weight-related condition such as high blood pressure or high cholesterol