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Strikingly, elevated histone Kla correlates with advanced tumor grade/stage and TME remodelingmanifested as increased immunosuppressive infiltrates (Tregs, M2 macrophages) and checkpoint molecule overexpression (PD-1, CTLA-4, LAG-3) (64, 65)

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Biol Trace Elem Res 2010, 138 (13), 272281

[10] In the research literature, MGF has been proposed to act early after muscle damage to mobilize satellite cells, whereas the systemic IGF-1 isoform (IGF-1Ea) and analogs like LR3 are framed as driving the later proliferative and anabolic phases though these distinctions come largely from cell and animal work and remain incompletely resolved