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Hawthorne effect with transient behavioral and biochemical changes in a randomized controlled sleep extension trial of chronically short-sleeping obese adults: implications for the design and interpretation of clinical studies

Following each 8-week phase, a two-week washout period was implemented before participants crossed over to the alternate condition

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The approximately 10-fold potency enhancement over native IGF-1 means that relatively small doses can produce substantial drops in blood glucose, particularly in fasted states, around exercise, or when combined with other glucose-lowering factors