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Costanza Alciati, a pharma analyst at GlobalData, told BioSpace in an email that GLP-1s will definitely dominate the market in the near future, but new entrants into the space are already looking for the next drug class that could revolutionize the space. Companies taking an alternative approach are forecast to capture only a very small portion of the obesity marketroughly 6.3%across the seven major markets (U.S., France, Germany, Italy, Spain, UK and Japan) by the end of 2031, according to Sara Reci, a senior analyst at GlobalData

2 Epidemiology & clinical burden As the most prevalent microvascular complication of diabetes mellitus, DKD remains the leading cause of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) worldwide (Loftus et al., 2022)

Maebashi M, Kawamura N, Sato M, Imamura A, Yoshinaga K

PK and PD analysis The PK of AMG 133 was evaluated using a validated liquid-chromatography tandem mass spectrometry (LCMS/MS) methodology to detect total AMG 133, defined as the GIPR-Ab with or without the GLP-1 analogue peptides and intact AMG 133, defined as the GIPR-Ab with at least one attached GLP-1 analogue peptide