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Similarly, a 2023 study published in the Journal of the American Medical Association (JAMA) found that individuals taking GLP-1 drugs were more than four times as likely to experience bowel obstruction compared with patients using bupropion-naltrexone, another class of weight-management medication

The pooled estimated change in HbA 1C from baseline to week 38 was 1.0%-point ( 11.2 mmol/mol)

Improvement in health conditions linked to weight gain Prediabetes, high blood pressure, high cholesterol, and insulin resistance often improve as weight decreases

[63] This was followed by the development of semaglutide by a team of researchers at Novo Nordisk, including Jesper Lau, Thomas Kruse, and Paw Bloch