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Studies of osteoblasts have revealed that GPER activation not only promotes the proliferation and differentiation of osteoblasts, thus affecting bone mineralization via the AMPK/ACC signaling pathway, but also inhibits mitochondrial autophagy in osteoblasts through the activation of the AKT pathway, reducing apoptosis [146]

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This octadecapeptide (18 amino acid units) has the composition: Arg,Asp 2 ,Glu 2 ,Gly 2 ,His,Lys 2 ,Met,Phe,Pro 3 ,Ser,Tyr 2 , and is abbreviated P 18

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