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Not unexpectedly, the top upregulated proteins following semaglutide treatment in STEP 1 and 2 (including in the weight-adjusted analysis) were related to digestive enzymes and the exocrine pancreas

Semaglutide stimulates insulin secretion from the pancreas when blood glucose levels are elevated, helping to lower blood sugar after meals

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There are no detectable GLP-1r on the liver or on skeletal muscle and yet GLP-1 has repeatedly been shown to not just increase insulin secretion but also to improve insulin sensitivity