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31 , 32 Los estudios clnicos ya han demostrado que la adicin de iSGLT2 a los iDPP4 mejora las concentraciones de glucosa con prdida significativa de peso, 33 , 34 y al tener en cuenta que los pacientes con diabetes mellitus tipo 2 tienen de base aumento del glucagn y de la gluconeognesis heptica, 35 - 39 se ven beneficiados con la administracin de AGLP1

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