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A 2025 University of Michigan study found states with largest Medicaid reductions saw: Higher rates of buprenorphine treatment discontinuation Increased cash payments for addiction medications Greater overdose risks from interrupted MAT access This proved particularly concerning since only 5% of Indiana Medicaid enrollees with opioid use disorder received treatment prior to unwinding

Women who are pregnant, planning pregnancy, or breastfeeding should avoid the compound entirely due to unknown effects on fetal and infant development

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