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In animal reproduction studies, adverse effects on development were observed following intranasal administration of dihydroergotamine mesylate during pregnancy (decreased fetal body weight and/or skeletal ossification) in rats and rabbits or during pregnancy and lactation in rats (decreased body weight and impaired reproductive function in the offspring) at doses that were not associated with maternal toxicity (see Data)

The ice nucleating properties of non-biological aerosols, including mineral dust 7,8 , anthropogenic soot and pollutants 9,10 are better understood, though in the case of soot, ice nucleation temperatures vary due to the influences of atmospheric aging, degree of oxidation, and ice nucleation mechanism 10,11,12,13

Specific deficiencies

Deficiency of Se in the serum of patients with GD increased with age and was correlated with an increased titer of antibodies to the TSH receptor (TRAb)