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This is reassuring as a starting point but cannot substitute for human safety data, particularly regarding long-term use, drug interactions, and effects in people with underlying conditions

Mechanism of Action Inhibits Nicotinamide N-Methyltransferase (NNMT) Increases intracellular nicotinamide and NAD levels Improves mitochondrial efficiency and energy metabolism Supports lipolysis and fat oxidation Reduces adipocyte (fat cell) growth and proliferation Modulates inflammatory pathways and insulin signaling These effects may lead to enhanced fat metabolism, better blood sugar regulation, improved endurance, and a general increase in metabolic flexibility

In subjects with T2D, LY3298176 reduced fasting glucose, glucose excursions and body weight with increasing doses