Modestly higher homocysteine, as predicted by genetics, was associated with an increased risk of stroke .[ref] High homocysteine levels can damage the endothelium (lining of the blood vessels) and cause hardening of the arteries.[ref] Related article : Heart disease genes Chronic diseases: Similarly, MR studies have shown that high homocysteine can cause metabolic syndrome , worsen osteoarthritis , increase the risk of cataracts, and increase the risk of Alzheimers disease
Interestingly, DSIP is also found in human breast milk, where it is present in higher concentrations, suggesting a potential role in promoting sleep in neonates, highlighting its natural significance
doi: 10.1093/humrep/deaa291 Summary Keywords antioxidant interventions, female fertility preservation, ovarian aging, oxidative stress, ROS Citation Xie B, Zhang K, Lin J, Cheng H and Huang X (2026) Female reproductive capacity preservation: antioxidant strategies in combating ovarian aging and cryopreservation challenges
2022;45(Suppl 1):S11324