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Massachusetts, Vermont, Rhode Island, and Connecticut include tirzepatide on their obesity treatment formularies under specific BMI and comorbidity criteria

Overall, the data demonstrate that ACLY and ACSS2 are not the sole sources of acetyl-CoA in the nuclear-cytosolic compartment, and that the carnitine shuttle participates in the transit of acetyl-CoA from mitochondria to cytosol to support lipogenesis and histone acetylation