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In mammals, yeast cadmium factor (YCF1) encodes a MgATP-fueled glutathione conjugate transporter responsible for transporting the di(glutathione)-cadmium complex to the vacuole for sequestration, a crucial pathway for cadmium detoxification
Additional roles confirmed included protein folding, cell cycle regulation, apoptosis, ferroptosis, and ascorbate metabolism
Tumor risk via p53 pathway interference Mitigate risk by: Careful patient selection: exclude patients with pre-existing active malignancy or high tumour risk (e.g., known p53 mutations, familial cancer syndromes)
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