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At the same time, pro-inflammatory processes are activated, which, among other things, cause muscle soreness

IGF-DES and the IGF-1R Signalling Network The IGF-1R is a cell-surface protein evolutionarily related to the insulin receptor, and its biological actions are moderated by IGFBPs that bind and transport the ligand in circulation

IGFBPs can also act to guide IGF-1 to specific tissues, or even to inhibit or potentiate IGF-1 actions by acting as an independent substrate for the IGF-1R and/or other specific membrane, intracellular or nuclear receptors [9395]