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HIDE SNPs have a higher level of integration than typical D-SNPs

The most quoted example is the follow-up of "The Biggest Loser" contestants: six years after the competition, resting metabolic rate was 704 kcal a day below where it started, and after adjusting for their body composition and age, 499 kcal a day of that was unexplained by size (Fothergill et al., 2016)

In addition, the GO analysis of genes enriched in terms of molecular function showed a prominent abundance of gene signatures associated with cytokine binding and C-X-C chemokine binding ( Figure 2C )

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