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1 Original Procognitive Characterization McCoy et al., Journal of Pharmacology and Experimental Therapeutics (2013) This paper has been under Expression of Concern since 2021 (see disclosure block above)

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Phase 3 Retatrutide trials currently underway will address these gaps with larger, longer studies before FDA submission

The increased Gro3P then circulates to bone cells to stimulate the bone-derived hormone fibroblast growth factor 23 (FGF-23), which reduces blood phosphate levels by blocking kidney absorption, thus forming a kidney-bone feedback loop to maintain blood phosphate homeostasis 44