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Step 3: Triglyceride Hydrolysis and Fat Release The activation of hormone-sensitive lipase represents the critical step in fat cell targeting

Through co-immunoprecipitation (CO-IP) experiments, we discovered that FOXO4-DRI prevents the binding of FOXO4 to P53, facilitating the phosphorylated P53 nuclear exclusion, which subsequently trigger BAX and cleaved caspase-3, leading to the apoptosis of senescent cells

The inability of megakaryocytes to mature properly results in thrombocytopenia

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