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During unusual circumstances, such as the COVID-19 pandemic, the approach to managing chronic conditions like pernicious anaemia, which requires regular B12 injections, had to be adapted, potentially influencing the perception of efficacy and safety of the treatment among patients

Furthermore, viral protein nsp5 and nsp14 interact with host redox-enzymes: glutathione peroxidase (GPx) and peroxiredoxin (Prx), in both cytoplasm and mitochondria to dysregulate redox balance in different cellular compartments and enhance SARS-CoV-2 infection 21

At present, three main types of drugs promote the occurrence of ferroptosis by weakening ferroptosis inhibitors: those that directly regulate the level of free iron and weaken the ferroptosis inhibitors present in the iron metabolism process