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Diabetologia 65(Suppl 1):S288S288 Samms RJ, Zhang G, He W et al (2022) Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue
In its Acceleration Plan to Stop Obesity, adopted in 2022, WHO highlights many different factors contribute to obesity and that the matter is not just a matter of individual responsibility
However, other investigations have suggested that several GLP-1RAs may cross the bloodbrain barrier via passive diffusion 251 , a GLP-1R-mediated uptake mechanism 252 or adsorption transcytosis 253 , although different compounds may present with variable degrees of brain penetrance 254