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doi: 10.1016/j.alcr.2013.12.002 241

Canagliflozin was associated with a decrease in total hip bone mineral density over 104 weeks, (placebo-subtracted changes:100mg -0.9% and 300mg -1.2%), but did not result in changes in bone mineral density in the femoral neck, lumbar spine, or distal forearm (227)

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Acceptable if you are taking antibiotics to prevent an infection for the following reasons: acne, chronic prostatitis, dry eye, peptic ulcer disease, periodontal disease, pre-dental work, rosacea, ulcerative colitis, after a splenectomy or valvular heart disease