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Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses

In developed countries, excessive calorie intake and frequent consumption of unhealthy foods, associated with a sedentary lifestyle, have caused an increase in the prevalence of obesity, which in turn predisposes to several non-communicable diseases, such as cardiovascular disease, diabetes, hypertension, and chronic kidney disease [9]

The labeled titration schedule remains the operative instruction [6]