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According to a review conducted by the European Medicines Agency safety committee in 2025, non-arteritic anterior ischemic optic neuropathy is a very rare side effect of semaglutide that could affect 1 in 10,000 people 33

Dietary and oral supplementation are the most common ways of achieving adequate B12 levels, but this can be challenging for certain individuals depending on their diet, intestinal health, ability to convert to active forms and other health conditions

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