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Under normal physiological conditions, up to about 9098% of cellular glutathione is in the reduced GSH form, and a shift toward higher GSSG levels is widely used as an indicator of oxidative stress and impaired cellular health

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Cook SF, King AD, van den Anker JN et al , Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: method validation and application to a neonatal pharmacokinetic study