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This phenotype was explored in both mouse models and in vitro with an anti-IL-23 antibody to block IL-23 signaling where mice experienced prolonged survival and decreased tumor burden, and CD8 + cells in mice and in vitro showed enhanced cytotoxicity in the IL-23-depleted state [154] (Fig

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In mammals, this temporal coordination is achieved through a hierarchical circadian timing system composed of a master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus and multiple peripheral clocks distributed across metabolic organs, including the liver (22, 23)

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