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Variants in the GLP1R gene (such as rs6923761) may affect medication efficacy and tolerability

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Regarding CC, the enriched components mainly located in the membrane raft, perinuclear region of cytoplasm, and receptor complex, suggesting the functions of cellular trafficking and signaling transduction within specific cellular structures

However, clinical research increasingly recognized that patients with metabolic diseases frequently experience clusters of systemic complications, including heart failure (HF), chronic kidney disease (CKD), and fatty liver disease, that single-target drugs historically failed to address comprehensively