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hence, the dual and tri-agonists that are now in the pipeline. Assessing the STEPs For the four phase 3 STEP trials, researchers assessed semaglutide 2.4 mg in more than 4,300 adults with obesity or overweight with a weight-related comorbid condition

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The STEP (Semaglutide Treatment Effect in People with Obesity) clinical trial program provided robust evidence for semaglutides efficacy: STEP 1: Participants receiving semaglutide 2.4 mg weekly lost an average of 14.9% of body weight over 68 weeks, compared to 2.4% for placebo (Wilding et al., New England Journal of Medicine , 2021) STEP 2: In patients with type 2 diabetes, semaglutide produced 9.6% weight loss over 68 weeks STEP 3: Combined with intensive behavioral therapy, semaglutide produced 16.0% weight loss STEP 5: Weight loss was maintained over 104 weeks with continued treatment Head-to-Head Comparison: Mechanism of Action The fundamental difference between tesofensine and semaglutide lies in where and how they act in the body