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Second, DPP4 degrades both GLP-1 and gastric inhibitory polypeptide (GIP), yet metformin treatment in humans only increases the GLP-1 concentration, whereas DPP4 inhibitors increase both GLP-1 and GIP concentrations [60, 61]

While the FDA regulates all prescription and over-the-counter drugs, they do not regulate or approve drugs made in compounding pharmacies

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