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Blood glucose levels are tightly regulated within a very narrow range in individuals with normal glucose tolerance, which is maintained by the coordinated action of islet and incretin hormones, as well as neural and humoral factors from different tissues and organs

Direct effects GLP-1R mRNA and protein have been detected in human renal vascular smooth muscle cells of afferent and efferent arterioles, interlobular and arcuate arteries, and juxtaglomerular and proximal tubular cells [56]

The relative influences of other factors on discontinuation are unclear, including changes in insurance coverage, high out-of-pocket costs, medication shortages [71], or false cessation due to switching to compounded (pharmacy prepared) GLP-1s

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