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When adriamycin induces aging in ATDC5 chondrocytes, catalpol delays the progression of knee osteoarthritis by promoting apoptosis and reducing aging-related phenotypes such as P21 and P53, as well as MMP13 and IL-6 ( In summary, catalpol effectively inhibits inflammation, oxidative stress, and apoptosis, influencing multiple related signaling pathways to treat arthritis

However, its medical application is limited by several physicochemical and pharmacokinetic disadvantages, including low solubility and bioavailability, hydrophobicity, rapid metabolism and systemic elimination, and low absorption and high photosensitivity

M.Alzheimer's Disease Neuroimaging Initiative (2020)