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It is currently being investigated for its role in cellular signalling, tissue-level processes, and peptide interaction pathways

Recently, HIF activation and inhibition have emerged as therapeutic targets in various human diseases

A positive development is that the estimated prevalence of AMD in Americans 40 and older has decreased from 9.4% in the years 1988-1994 to 6.5% in the years 2005-2008 (Klein 2011)

Another study on a rat model of gouty arthritis, induced by MSU crystals and followed by a 5-day administration of rutin, found that rutin reduced ankle swelling, and the levels of MDA and NO, and improved the activities of GSH-peroxidase, SOD and catalase in rats (25)