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Certain situations may require individualized evaluation, but treatment outside approved indications is determined by healthcare providers based on medical judgment and patient-specific circumstances

The MTHFR enzyme is important to homocysteine metabolism as it is necessary to transfer a methyl group to the methionine

In addition, recovery periods after surgery or illness can involve reduced movement, which may temporarily affect circulation and increase the chance of clot formation

Visceral fat and IGF-1 are meaningful measures, but they are surrogate/intermediate endpoints, not hard clinical outcomes like cardiovascular events