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Remodeling lipid metabolism, particularly the redistribution of oxidizable PUFAs, leads to increased lipid peroxidation and induces ferroptosis in tumors [17]

Studies such as LEADER, SUSTAIN-6, and REWIND (dulaglutide) have shown these agents are indispensable for patients with T2DM and established CVD or high CV risk

All data are from the VUMC Synthetic Derivative (SD) database, a de-identified copy of the main hospital medical record database created for research purposes

Large randomized controlled trials, including the STEP trials, demonstrated consistent weight loss of 15-22% over 68 weeks using the standard once-weekly dosing protocol starting at 0.25 mg and titrating to 2.4 mg