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It often slows down digestion, which can help you feel full longer, but it can also cause side effects like nausea, vomiting, or constipation

The depletion of GSH inactivates GPX4, which then fails to clear lipid hydroperoxides generated from the oxidation of PUFAs in cell membranes, thereby exacerbating lipid peroxidation cascades

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To help these patients, the FDA recently approved the treatment with topical ruxolitinib, a new JAK used orally for the treatment of myelofibrosis [6] and hematological tumors [7], but when applied topically leads to the re-pigmentation of previously blanched patches [8]