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Moreover, such endogenous brain proteins, cross-seeded to induce aggregation into toxic oligomers, could become the pernicious species responsible for growth of slowly expanding lesions in progressive MS, or form tiny islands of deposited seed to which microglia react to form nodules in pre-lesions

Health Risks of Vitamin B12 Deficiency If not treated immediately, a B12 deficiency may pose serious health complications, including permanent nerve damage, mental health concerns, and a heightened risk of heart disease

This does not indicate failure

Genetic variations in VDBP/( CYP2R1 ) are known to influence 25(OH)VD blood levels in response to VD supplementation (13, 19, 23, 29, 30, 52)