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Additionally, the intricate combinatorial nature of miRNA-mRNA interactions renders the concentration of mimics or inhibitors a crucial yet poorly comprehended factor affecting their targetome. Consequently, meticulously refining chemical design, delivery mechanisms, and dosage protocols while examining the intricate impacts of miRNA or siRNA concentrations on gene networks will be crucial for surmounting specificity challenges and completely harnessing the therapeutic potential of RNA-based cancer therapies [334]

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