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Layering matters because tretinoin is powerful and unstable

Glutathione deficiency increases susceptibility to oxidative stress, which may be the underlying cause of many diseases including cancer, heart disease, Parkinsons, and Alzheimers [8]

Smaller doses usually mean smaller risk of side effects

[320] We appreciate commenters' recommendation regarding stratification based on ED volume and note that ED volume is a facility-level characteristic, rather than a patient-case characteristic, although we will take this into consideration as we monitor implementation of this measure and consider any potential future refinements