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NICE guidance on diabetes management (NG28) emphasises the importance of supporting patients through adverse effects to optimise treatment adherence and outcomes

Due to reductions in appetite associated with GLP-1RA therapy, there is also the potential for consumption of dietary protein to be inadequate

Working closely with her diabetes care team, she found that a lower microdose of 0.15 mg, drawn from the pen using a U-100 insulin syringe, was effective

"With these positive data in hand, we are now planning to submit orforglipron for regulatory review by year-end and are prepared for a global launch to address this urgent public health need." According to Eli Lilly, adults in the Phase 3 trials all lost weight with orforglipron and on the highest dose of 36 mg of orforglipron, the trial participants lost about 27 pounds over the course of 72 weeks or about 12% of their body weight, which is meaningful but not quite as high as some injectables