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3.2 Advantages, Limitations, and Applications of GO Analysis The primary advantage of Gene Ontology (GO) lies in its detailed granularity and standardized hierarchical structure, which enables precise functional interpretation across diverse biological systems

Our results provide a possible mechanism in which upregulation of phosphorylated p53 and p16 maintain the cell cycle arrest of keloid fibroblasts, and FOXO4-DRI selectively induces apoptosis of keloid senescent fibroblasts by prompting p53-pS15 nuclear exclusion

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