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Importantly, when supplementation ended, glutathione levels gradually returned to baseline, demonstrating the importance of consistent daily supplementation

Eur J Neurosci 12:37218, PMID: 11029642 Matsuzawa D, Obata T, Shirayama Y, Nonaka H, Kanazawa Y, Yoshitome E, Takanashi J, Matsuda T, Shimizu E, Ikehira H, Iyo M, Hashimoto K (2008) Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3 T 1H-MRS study

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A phase III clinical trial was then designed to further examine the effect of high-dose coenzyme Q 10 (1,200-2,400 mg/day) and vitamin E (1,200 IU/day) supplementation on both motor and non-motor symptoms associated with Parkinsons disease