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Preclinical studies indicate that uncommon populations of intrahepatic GLP-1R-expressing cells, especially endothelial cells and T cells, contribute to the therapeutic benefits

Nadia Ahmad, the medical director for obesity medical development at Eli Lilly, told Insider earlier this year

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By regulating gastric emptying, GLP-1 not only aids in short-term appetite control but may also contribute positively to long-term energy balance and weight management.176 GLP-1RAs and diseases As a rising star in recent years, GLP-1RAs are not only effective in metabolic diseases but also play a role in non-metabolic disorders, affecting multiple systems including the musculoskeletal, nervous, cardiovascular, and digestive systems, and can even have implications in oncological diseases