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Endogenous MOTS-c levels also decline with age, which helps explain why metabolic efficiency tends to drop in our 40s and 50s regardless of diet or exercise

These conditions are characterized by cellular stress, chronic inflammation, and disrupted lipid and glucose metabolism, all of which are influenced by UPS activity (Fig

Comparative renal outcomes of matched cohorts of patients with type 2 diabetes receiving SGLT2 inhibitors or GLP-1 receptor agonists under routine care