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A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.ly/Q02QBfSp0 GLP-1 receptor agonists, which are effective for weight loss, can cause substantial muscle loss

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In clinical trials, participants who did not consistently follow the dosing schedule lost an average of 13.6 percent of body weight, compared with 16.6 percent among those who adhered closely

GDF8 GDF8 inhibits fatty acid oxidation in adipose tissue, hinders the formation of brown adipose tissue, and reduces glucose uptake in liver tissue [3]