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The combination may result in more severe or prolonged gastrointestinal symptoms, potentially leading to dehydration, electrolyte imbalances, or nutritional deficiencies if food intake becomes severely restricted

In the SUSTAIN 3 trial, once-weekly semaglutide 1 mg was more efficacious than exenatide ER across all three tested endpoints, and in the SUSTAIN 7 trial, both once-weekly semaglutide 0.5 mg and 1 mg were more efficacious than dulaglutide 0.75 mg and 1.5 mg across all three tested endpoints, based on the retrieved dropout analysis

Evidence Checklist for Your Consultation The legal system changed in August 2025, when court rulings (MDL 3094) established stricter requirements for objective medical proof