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Activation of the GLP-1R by GLP-1 also results in recruitment of -arrestin-1 (Arr1) and -arrestin-2 (Arr2), which mediate receptor internalization and may serve as scaffolds for G protein-independent signaling ( 18, 19 )
Ephelides do not undergo malignant transformation, but they are considered to be a sign of UV-induced skin damage, and their presence correlates with an increased lifetime risk of malignant melanoma [11]
Wilding JP, Batterham RL, Calanna S, et al
