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These dual biochemical effects make it a focal point for research on metabolic reprogramming and longevity

E1 and E2 enzymes: upstream regulators of cardiac ubiquitination capacity E1 activators: gatekeepers of the UPS pathway The UPS pathway begins with the activation of ubiquitin by E1 activators, also known as ubiquitin-like modifier activating enzymes (UBA1-UBA7)

Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies

Energy stress-mediated AMPK activation and the activation of the Nrf2 antioxidant pathway also play important roles in regulating ferroptosis, through which metformin could alleviate ferroptosis and vascular calcification in high-lipid model mice