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A human study showed that GLP-1 significantly delayed gastric emptying but did not affect gastric muscle contractility or water homeostasis, suggesting GLP-1 inhibits gastric emptying through an indirect mechanism rather than altering muscle contractility directly [121]

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It works by mimicking glucagon-like peptide-1 (GLP-1), a hormone naturally produced in the gut, which regulates appetite, promotes satiety, and stabilizes blood sugar levels

In the clinical trials of retatrutide, dose escalation was paused or reduced when participants experienced intolerable side effects, most commonly gastrointestinal symptoms such as nausea, vomiting, or diarrhoea